ea0098b13 | Basic Science | NANETS2023
Wang Zoey
, Qureshi Areeba
, Kulathunga Nilakshi
, Schuurmans Carol
, Hansen He Housheng
, Michael Iacovos
Background: Pancreatic neuroendocrine tumours (PanNETs) are an understudied cancer type characterised by frequent metastasis, clinical recurrence, and high mortality rate. PanNETs originate from pancreatic islets, primarily β cells, and comprise two molecular subtypes: poorly invasive, relatively benign islet tumour (IT) and highly aggressive metastasis-like primary (MLP) tumour. The MLP subtype arises from IT through a switch in cell fate involving the acquisition of neu...